The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

被引:344
|
作者
Vitali, A. [1 ]
Murano, I. [1 ]
Zingaretti, M. C. [1 ]
Frontini, A. [1 ]
Ricquier, D. [2 ,3 ]
Cinti, S. [1 ,4 ]
机构
[1] Univ Ancona, Politecn Della Marche, Dept Expt & Clin Med, I-60020 Ancona, Italy
[2] Univ Paris 05, CNRS, Paris, France
[3] Univ Paris 05, INSERM, Cochin Inst, Paris, France
[4] IRCCS San Rafele Pisana, Adipose Organ Lab, I-00163 Rome, Italy
关键词
adipose tissue; beta-oxidation; diabetes; innervations; transdifferentiation; NERVE GROWTH-FACTOR; DIET-INDUCED OBESITY; TISSUE; FAT; EXPRESSION; RATS; BETA(3)-ADRENOCEPTOR; TRANSDIFFERENTIATION; DIFFERENTIATION; IDENTIFICATION;
D O I
10.1194/jlr.M018846
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures. Most of the fat tissue was contained in depots with discrete anatomical features, and most depots contained both white and brown adipocytes. Quantitative analysis showed that cold acclimation induced an increase in brown adipocytes and an almost equal reduction in white adipocytes; however, there were no significant differences in total adipocyte count or any signs of apoptosis or mitosis, in line with the hypothesis of the direct transformation of white into brown adipocytes. The brown adipocyte increase was accompanied by enhanced density of noradrenergic parenchymal nerve fibers, with a significant correlation between the density of these fibers and the number of brown adipocytes. Comparison with data from obesity-resistant Sv129 mice disclosed a significantly different brown adipocyte content in C57BL/6J mice, suggesting that this feature could underpin the propensity of the latter strain to develop obesity.(jlr) However, the greater C57BL/6J browning capacity can hopefully be harnessed to curb obesity and type 2 diabetes in patients with constitutively low amounts of brown adipose tissue.-Vitali, A., I. Murano, M. C. Zingaretti, A. Frontini, D. Ricquier, and S. Cinti. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J. Lipid Res. 2012. 53: 619-629.
引用
收藏
页码:619 / 629
页数:11
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