Electrical modeling of the cell-electrode interface for recording neural activity from high-density microelectrode arrays

被引：51

作者：

Joye, Neil ^{[1
]}

Schmid, Alexandre ^{[1
]}

Leblebici, Yusuf ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, STI IEL LSM, CH-1015 Lausanne, Switzerland

来源：

NEUROCOMPUTING | 2009年 / 73卷 / 1-3期

关键词：

Cell-electrode electrical model; Extracellular signal recording; High-density microelectrode array; Subcellular resolution; Three-dimensional tip electrode; PLATINUM-ELECTRODES; SIGNAL TRANSFER; IN-VITRO; STIMULATION; NEURONS; SYSTEM; RESISTANCE;

D O I：

10.1016/j.neucom.2009.09.006

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

Accurate electrical models are needed to support the design of modern microelectrode arrays. The point-contact model is presented thoroughly, and an area-contact model is analytically derived in order to model the electrical characteristics of the cell-electrode interface at subcellular resolution. An optimum electrode diameter for recording the electrical activity of neurons is analytically determined at 8 mu m, with a cell diameter of 10 mu m and a typical load capacitance of 10 pF. Finally, three-dimensional tip electrodes are characterized using the area-contact model. An improvement of the electrical coupling up to 20 dB is observed for small electrodes, in simulation. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：250 / 259

页数：10

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