This paper aims to analyze the question of the anthropological sense in two egregious Spanish philosophers. The first great block will be devoted to exploring - following Jose Ortega y Gasset - how authentic life is genuinely projective, in which personal meaning is developed. In this way we can delve into notions as relevant as the vocation, the destiny or the fund incorruptible of existence. In the second and last part, Jose Gomez Caffarena will help us to ask on whether the experience of meaning is inseparable from the great question for the Sense, understood as the metaphysical horizon of human life.