Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates

被引：105

作者：

Wang, Qiang ^{[1
]}

Qi, Xiaotian ^{[2
]}

Lu, Liang-Qiu ^{[1
]}

Li, Tian-Ren ^{[1
]}

Yuan, Zhi-Guang ^{[1
]}

Zhang, Kai ^{[1
]}

Li, Bin-Fie ^{[1
]}

Lan, Yu ^{[2
]}

Xiao, Wen-Jing ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China

[2] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400030, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 08期

基金：

中国国家自然科学基金;

关键词：

cycloaddition; density-functional calculations; heterocycles; iron; ylides; SULFUR YLIDES; VINYLETHYLENE CARBONATES; ALLYLIC CARBONATES; CASCADE REACTIONS; CONSTRUCTION; CYCLOPROPANATION; INDOLES; FE; REGIOSELECTIVITY; ACTIVATION;

D O I：

10.1002/anie.201510413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of iron-catalyzed decarboxylative (4+ 1) cycloaddition reactions is described in this publication. By using this method, a wide range of functionalized indoline products were prepared from easily available vinyl benzoxazinanones and sulfur ylides in high yields and selectivities. A possible reaction pathway involving an allylic iron intermediate is discussed based on a series of control experiments and density-functional theory calculations.

引用

页码：2840 / 2844

页数：5

共 20 条

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