SARS-CoV-2 and neurological disorders: the revelance of biomarkers?

被引：1

作者：

Bigot-Corbel, Edith ^{[1
]}

Lanore, Aymeric ^{[2
]}

Raulet, Celia ^{[3
]}

Delorme, Cecile ^{[2
,4
]}

Azulay, Jean-Philippe ^{[5
,6
]}

Lehmann, Sylvain ^{[7
,8
]}

Beaudeux, Jean-Louis ^{[9
]}

Beauvieux, Marie-Christine ^{[10
,11
]}

Sapin, Vincent ^{[12
]}

Peoc'h, Katell ^{[3
,13
]}

Rucheton, Benoit ^{[14
]}

机构：

[1] CHU Nantes, Hop Laennec, Lab Biochim, St Herblain, France

[2] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Dept Neurol, Paris, France

[3] Hop Bichat Claude Bernard, AP HP, Serv Biochim, Paris, France

[4] Sorbonne Univ, Paris Brain Inst, ICM, INSERM,U1127,CNRS,UMR 7225, Paris, France

[5] Hop La Timone, Serv Neurol & Pathol Mouvement, Ctr Expert Parkinson, Ctr Competences Malad Rares Mouvement & Cognit, Marseille, France

[6] SFN, Marseille, France

[7] CHU, Hop St Eloi, Inst Med Regeneratrice & Biotherapies IRMB, Lab Biochim Proteom Clin,CCBHM, Montpellier, France

[8] Univ Montpellier, Fac Med, INSERM, U1040, Montpellier, France

[9] Hop Necker Enfants Malad, AP HP, Serv Biochim Gen, Paris, France

[10] CHU Bordeaux, Serv Biochim, Bordeaux, France

[11] Univ Bordeaux, CNRS, UM5536, Bordeaux, France

[12] CHU, Serv Biochim & Genet Mol, Clermont Ferrand, France

[13] Univ Paris, UFR Med Xavier Bichat, Paris, France

[14] Sorbonne Univ, Hop Univ Pitie Saipetriere, AP HP, DMU BioGeM,Serv Biochim Metab, Paris, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2021年 / 79卷 / 01期

关键词：

SARS-CoV-2; Covid-19; neuroinflammation; neurological impairment; cerebrospinal fluid; biomarkers; INFECTION; COVID-19;

D O I：

10.1684/abc.2021.1622

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

*Soon after the pandemic, numerous publications described cases of neurological disorders associated with the SARS-CoV-2 infection. The range of neurological symptoms is becoming increasingly more extensive as the pandemic progresses. However, it is not yet well established whether the manifestations are due to direct viral damage to the nervous system or indirect consequences of the infection. This review presents an inventory of the biochemical markers studied in the context of neurological disorders related to SARS-CoV-2. By reflecting various physiopathological mechanisms, these biomarkers allow both a better understanding of the pathophysiology of Covid-19 and a contribution to the diagnosis of neurologic troubles; they could participate in the prognostic evaluation of patients.

引用

页码：7 / 16

页数：10

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