Lung-targeted delivery system of curcumin loaded gelatin microspheres

被引：31
|
作者：
Cao, Fengliang [2 ]
Ding, Buyun [1 ]
Sun, Min [1 ]
Guo, Chenyu [1 ]
Zhang, Lin [1 ]
Zhai, Guangxi [1 ]
机构：
[1] Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
[2] Shandong Univ Hosp, Dept Pharm, Jinan 250012, Peoples R China
来源：
DRUG DELIVERY | 2011年 / 18卷 / 08期
关键词：
Microspheres; lung-targeted; curcumin; gelatin; emulsification-linkage; DRUG-RELEASE; ALBUMIN MICROSPHERES; CANCER-CELLS; IN-VITRO; PHARMACOKINETICS; 5-FLUOROURACIL; FORMULATION; PARAMETERS; CLEARANCE; BLOOD;
D O I：
10.3109/10717544.2011.595842
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of the study is to design and evaluate curcumin loaded gelatin microspheres (C-GMS) for effective drug delivery to the lung. C-GMS was prepared by the emulsification-linkage technique and the formulation was optimized by orthogonal design. The mean encapsulation efficiency and drug loading of the optimal C-GMS were 75.5 +/- 3.82 % and 6.15 +/- 0.44%, respectively. The C-GMS presented a spherical shape and smooth surface with a mean particle diameter of 18.9 mu m. The in vitro drug release behavior of C-GMS followed the first-order kinetics. The tissue distribution showed that the drug concentrations at lung tissue for the C-GMS suspension were significantly higher than those for the curcumin solution, and the Ce for lung was 36.19. Histopathological studies proved C-GMS was efficient and safe to be used as a passive targeted drug delivery system to the lung. Hence, C-GMS has a great potential for the targeted delivery of curcumin to the lung.
引用
收藏
页码：545 / 554
页数：10
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