PULMONARY COMPLICATIONS OF SICKLE CELL DISEASE

被引：8

作者：

Khoury, Ruby A. ^{[1
]}

Musallam, Khaled M. ^{[2
]}

Mroueh, Salman ^{[3
]}

Abboud, Miguel R. ^{[1
]}

机构：

[1] Amer Univ Beirut, Childrens Canc Ctr Lebanon, Dept Paediat & Adolescent Med, Med Ctr, Beirut, Lebanon

[2] Amer Univ Beirut, Dept Internal Med, Med Ctr, Beirut, Lebanon

[3] Amer Univ Beirut, Div Pulmonol, Dept Paediat & Adolescent Med, Med Ctr, Beirut, Lebanon

来源：

HEMOGLOBIN | 2011年 / 35卷 / 5-6期

关键词：

Sickle cell disease; Acute chest syndrome (ACS); Pulmonary hypertension; Asthma; ACUTE CHEST SYNDROME; LUNG-FUNCTION; PLASMA ENDOTHELIN-1; CHRONIC TRANSFUSION; NITRIC-OXIDE; YOUNG-ADULTS; CHILDREN; HYPERTENSION; HEMOLYSIS; ANEMIA;

D O I：

10.3109/03630269.2011.621149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pulmonary complications of sickle cell disease are a major cause of morbidity and mortality in affected patients. The acute chest syndrome (ACS) is a leading cause of death in patients with sickle cell disease and has a multifactorial etiology. Hydroxyurea (HU), stem cell transplantation (SCT) and chronic transfusions are known to prevent the recurrence of ACS. Careful management of patients admitted for pain crises and surgery including use of incentive spirometry is critical in preventing this complication. Pulmonary hypertension is well known to be associated with sickle cell disease and patients with pulmonary hypertension have increased mortality. Asthma is also commonly seen in patients with sickle cell disease and is associated with a more complicated course. Chronic lung disease develops in a significant proportion of patients with sickle cell disease.

引用

页码：625 / 635

页数：11

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