Synthesis and biological evaluation of small molecules inhibitors targeting heterotrimeric Gαi2 protein

被引：0
|
作者：
Caggia, Silvia [1 ]
Garrett, Autumn S. [1 ]
Kumar, Aditi [1 ]
Tapadar, Subhasish [2 ]
Oyelere, Adegboyega K. [2 ]
Venugopal, Smrruthi Vaidegi [1 ]
Khan, Shafiq A. [1 ]
机构：
[1] Clark Atlanta Univ, Atlanta, GA 30314 USA
[2] Georgia Tech, Sch Chem & Biochem, Atlanta, GA USA
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.SABCS18-4596
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4596
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Small Molecule Inhibitors Targeting Gαi2 Protein Attenuate Migration of Cancer Cells
    Caggia, Silvia
    Tapadar, Subhasish
    Wu, Bocheng
    Venugopal, Smrruthi V.
    Garrett, Autumn S.
    Kumar, Aditi
    Stiffend, Janae S.
    Davis, John S.
    Oyelere, Adegboyega K.
    Khan, Shafiq A.
    [J]. CANCERS, 2020, 12 (06) : 1 - 15
  • [2] Small molecules targeting heterotrimeric G proteins
    Ayoub, Mohammed Akli
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 826 : 169 - 178
  • [3] HIV-1 Nef Impairs Heterotrimeric G-protein Signaling by Targeting Gαi2 for Degradation through Ubiquitination
    Chandrasekaran, Prabha
    Buckley, Monica
    Moore, Victoria
    Wang, Long Qin
    Kehrl, John H.
    Venkatesan, Sundararajan
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (49) : 41481 - 41498
  • [4] Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2
    Bissinger, Rosi
    Lang, Elisabeth
    Ghashghaeinia, Mehrdad
    Singh, Yogesh
    Zelenak, Christine
    Fehrenbacher, Birgit
    Honisch, Sabina
    Chen, Hong
    Fakhri, Hajar
    Umbach, Anja T.
    Liu, Guilai
    Rexhepaj, Rexhep
    Liu, Guoxing
    Schaller, Martin
    Mack, Andreas F.
    Lupescu, Adrian
    Birnbaumer, Lutz
    Lang, Florian
    Qadri, Syed M.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [5] Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2
    Rosi Bissinger
    Elisabeth Lang
    Mehrdad Ghashghaeinia
    Yogesh Singh
    Christine Zelenak
    Birgit Fehrenbacher
    Sabina Honisch
    Hong Chen
    Hajar Fakhri
    Anja T. Umbach
    Guilai Liu
    Rexhep Rexhepaj
    Guoxing Liu
    Martin Schaller
    Andreas F. Mack
    Adrian Lupescu
    Lutz Birnbaumer
    Florian Lang
    Syed M. Qadri
    [J]. Scientific Reports, 6
  • [6] Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors
    Hati, Santanu
    Madurkar, Sanjay M.
    Bathula, Chandramohan
    Thulluri, Chiranjeevi
    Agarwal, Rahul
    Siddiqui, Faiza Amber
    Dangi, Poonam
    Adepally, Uma
    Singh, Ashutosh
    Singh, Shailja
    Sen, Subhabrata
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 100 : 188 - 196
  • [7] Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
    Ngai, Jacob
    Inngjerdingen, Marit
    Berge, Torunn
    Tasken, Kjetil
    [J]. BMC IMMUNOLOGY, 2009, 10
  • [8] Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
    Jacob Ngai
    Marit Inngjerdingen
    Torunn Berge
    Kjetil Taskén
    [J]. BMC Immunology, 10
  • [9] Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A
    Chishiki, Kanako
    Kamakura, Sachiko
    Yuzawa, Satoru
    Hayase, Junya
    Sumimoto, Hideki
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 435 (03) : 414 - 419
  • [10] Heterotrimeric G-protein subunit G alpha(i2) contributes to agonist-sensitive apoptosis and degranulation in murine platelets
    Cao, Hang
    Qadri, Syed M.
    Lang, Elisabeth
    Pelzl, Lisann
    Umbach, Anja T.
    Leiss, Veronika
    Birnbaumer, Lutz
    Nuernberg, Bernd
    Pieske, Burkert
    Voelkl, Jakob
    Gawaz, Meinrad
    Bissinger, Rosi
    Lang, Florian
    [J]. PHYSIOLOGICAL REPORTS, 2018, 6 (17):
12345