Nickel-Catalyzed [3+2+2] Cycloaddition of Ethyl Cyclopropylideneacetate and Heteroatom-Substituted Alkynes: Application to Selective Three-Component Reaction with 1,3-Diynes

被引：55

作者：

Yamasaki, Ryu ^{[1
]}

Terashima, Natsuki ^{[1
]}

Sotome, Ikuo ^{[1
]}

Komagawa, Shunsuke ^{[1
]}

Saito, Shinichi ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Chem, Fac Sci, Shinjuku Ku, Tokyo 1628601, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 02期

关键词：

PAUSON-KHAND REACTIONS; COCYCLIZATION; COMPLEXES; YNAMIDES; DIYNES;

D O I：

10.1021/jo902251m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heteroatom-substituted alkynes such as ynol ethers and ynamines turned out to be decent substrates for the Ni-catalyzed [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate (1). The three-component cocyclization of 1, 1,3-diynes, and heteroatom-substituted alkynes also proceeded selectively. The study provided all efficient method for the synthesis of heteroatom-substituted cycloheptadiene and related compounds.

引用

页码：480 / 483

页数：4

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