Co-occurring gain-of-function mutations in HER2 and HER3 cooperate to enhance HER2/HER3 binding, HER-dependent signaling, and breast cancer growth

被引:2
|
作者
Hanker, A. B.
Koch, J. P.
Ye, D.
Sliwoski, G.
Sheehan, J.
Kinch, L. N.
Brewer, M. Red
He, J.
Miller, V. A.
Lalani, A. S.
Cutler, R. E., Jr.
Croessmann, S.
Zabransky, D. J.
Meiler, J.
Arteaga, C. L.
机构
[1] UT Southwestern Med Ctr, Nashville, TN USA
[2] Vanderbilt Univ, Med Ctr, Nashville, TN USA
[3] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA
[4] Fdn Med, Cambridge, MA USA
[5] Puma Biotechnol, Los Angeles, CA USA
[6] Johns Hopkins Univ, Baltimore, MD USA
关键词
D O I
10.1158/1538-7445.SABCS18-PD3-05
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PD3-05
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, breast cancer progression, and HER2 inhibitor sensitivity
    Hanker, Ariella B.
    Jayanthan, Harikrishna Sekar
    Ye, Dan
    Lin, Chang-Ching
    Akamatsu, Hiroaki
    Sheehan, Jonathan H.
    Koch, James P.
    Sudhan, Dhivya R.
    Brewer, Monica Red
    Servetto, Alberto
    He, Jie
    Miller, Vincent A.
    Lalani, Alshad S.
    Meiler, Jens
    Arteaga, Carlos L.
    [J]. CANCER RESEARCH, 2020, 80 (04)
  • [2] Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
    Hanker, Ariella B.
    Brown, Benjamin P.
    Meiler, Jens
    Marin, Arnaldo
    Jayanthan, Harikrishna S.
    Ye, Dan
    Lin, Chang-Ching
    Akamatsu, Hiroaki
    Lee, Kyung-Min
    Chatterjee, Sumanta
    Sudhan, Dhivya R.
    Servetto, Alberto
    Brewer, Monica Red
    Koch, James P.
    Sheehan, Jonathan H.
    He, Jie
    Lalani, Alshad S.
    Arteaga, Carlos L.
    [J]. CANCER CELL, 2021, 39 (08) : 1099 - +
  • [3] Essential role of Her3 in two signaling transduction patterns: Her2/Her3 and MET/Her3 in proliferation of human gastric cancer
    Yun, Chen
    Gang, Li
    Gu Rongmin
    Xu, Wen
    Ming Xuezhi
    Chen Huanqiu
    [J]. MOLECULAR CARCINOGENESIS, 2015, 54 (12) : 1700 - 1709
  • [4] Functional genomics of HER2 and HER3 mutations and response to neratinib
    Hanrahan, Aphrothiti J.
    Hyman, David M.
    Sfakianos, John
    Jones, Alexis
    Ramirez, Ricardo
    Johnsen, Hannah
    Lyer, Gopakumar
    Al-Ahmadie, Hikmat A.
    Bajorin, Dean
    Bochner, Bernard H.
    Coleman, Jonathan A.
    Rosenberg, Jonathan E.
    Berger, Michael F.
    Chandarlapaty, Sarat
    Baselga, Jose
    Solit, David B.
    [J]. CANCER RESEARCH, 2015, 75
  • [5] In situ detection of HER2:HER2 and HER2:HER3 protein–protein interactions demonstrates prognostic significance in early breast cancer
    Melanie Spears
    Karen J. Taylor
    Alison F. Munro
    Carrie A. Cunningham
    Elizabeth A. Mallon
    Chris J. Twelves
    David A. Cameron
    Jeremy Thomas
    John M. S. Bartlett
    [J]. Breast Cancer Research and Treatment, 2012, 132 : 463 - 470
  • [6] Overexpression of HER2/HER3 and clinical feature of ovarian cancer
    Chung, Ye Won
    Kim, Seongmin
    Hong, Jin Hwa
    Lee, Jae Kwan
    Lee, Nak Woo
    Lee, Young Seok
    Song, Jae Yun
    [J]. JOURNAL OF GYNECOLOGIC ONCOLOGY, 2019, 30 (05)
  • [7] Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2-Positive Breast Cancer
    Kanthala, Shanthi
    Banappagari, Sashikanth
    Gokhale, Ameya
    Liu, Yong-Yu
    Xin, Gu
    Zhao, Yunfeng
    Jois, Seetharama
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 85 (06) : 702 - 714
  • [8] HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer
    Saddawi-Konefka, Robert
    Schokrpur, Shiruyeh
    Lui, Asona J.
    Gutkind, J. Silvio
    [J]. CANCER JOURNAL, 2022, 28 (05): : 339 - 345
  • [9] Overexpression of HER2/HER3 and the clinical feature of ovarian cancer
    Kim, S.
    Ryu, K. J.
    Lee, S.
    Song, J. Y.
    [J]. GYNECOLOGIC ONCOLOGY, 2019, 154 : 96 - 96
  • [10] In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer
    Spears, Melanie
    Taylor, Karen J.
    Munro, Alison F.
    Cunningham, Carrie A.
    Mallon, Elizabeth A.
    Twelves, Chris J.
    Cameron, David A.
    Thomas, Jeremy
    Bartlett, John M. S.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2012, 132 (02) : 463 - 470