Characterization of extended-spectrum -lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China

被引：4
|
作者：
Berglund, Bjorn [1 ]
Chen, Baoli [2 ]
Tarnberg, Maria [1 ]
Sun, Qiang [3 ,4 ]
Xu, Liuchen [2 ]
Welander, Jenny [1 ,5 ]
Li, Yan [2 ]
Bi, Zhenwang [2 ]
Nilsson, Maud [1 ]
Nilsson, Lennart E. [1 ]
机构：
[1] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden
[2] Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
[3] Shandong Univ, Ctr Hlth Management & Policy, Jinan, Shandong, Peoples R China
[4] Shandong Univ, Key Lab Hlth Econ & Policy Res, Minist Hlth, Jinan, Shandong, Peoples R China
[5] Linkoping Univ, Dept Clin Microbiol, Linkoping, Sweden
来源：
FUTURE MICROBIOLOGY | 2018年 / 13卷 / 15期
基金：
中国国家自然科学基金;
关键词：
antibiotic resistance; colistin; ESBL; Escherichia coli; intestinal pathogenic E; coli; mcr-1; whole-genome sequencing; BETA-LACTAMASE; RESISTANCE GENE; CTX-M; ANTIMICROBIAL RESISTANCE; HIGH-RATES; PREVALENCE; EMERGENCE; PROVINCE; PIGS;
D O I：
10.2217/fmb-2018-0242
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To characterize extended-spectrum -lactamase-producing Escherichia coli harboring the colistin resistance gene mcr-1 from human fecal samples collected in 2012 in a rural area of Shandong province, PR China. Materials & methods: Whole-genome sequencing and antimicrobial susceptibility testing was performed on 25 mcr-1-positive isolates to determine carriage of antibiotic resistance and virulence genes, diversity and antibiotic resistance profiles. Results: The isolates were highly genetically diverse and carried a large variety of different antibiotic resistance genes. The multidrug-resistance rate was high (96%). Virulence genes associated with intestinal pathogenic E. coli were carried by 32% of the isolates. Conclusion: Further monitoring of the epidemiological situation is necessary to ensure a preparedness for potential emergence of novel, difficult-to-treat strains and awareness of available treatment options.
引用
收藏
页码：1647 / 1656
页数：10
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