Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study

被引:4
|
作者
McCaughey, C
Murray, LJ
McKenna, JP
Coyle, PV
O'Neill, HJ
Wyatt, DE
Woodside, JV
Yarnell, JWG
Ducimetiere, P
Bingham, A
Amouyel, P
Montaye, M
Arveiler, D
Haas, B
Ferrieres, J
Ruidavets, JB
机构
[1] Royal Hosp, Reg Virus Lab, Belfast BT12 6BA, Antrim, North Ireland
[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[3] Queens Univ Belfast, Dept Med, Belfast BT12 6BJ, Antrim, North Ireland
[4] Hop Paul Brousse, INSERM, U258, F-94807 Villejuif, France
[5] Inst Pasteur, INSERM, U508, F-59019 Lille, France
[6] Lab Epidemiol & Sante Publ, Strasbourg, France
[7] Fac Med Purpan, INSERM, U558, Toulouse, France
关键词
D O I
10.1186/1471-2334-5-61
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Coxiella burnetii causes the common worldwide zoonotic infection, Q fever. It has been previously suggested that patients who had recovered from acute Q fever (whether symptomatic or otherwise) may be at increased risk of ischaemic heart disease. We undertook this study to determine if past infection with Coxiella burnetii, the aetiological agent of Q fever, is a risk factor for the subsequent development of ischaemic heart disease. Methods: A nested case-control study within the Prospective Epidemiological Study of Myocardial Infarction (PRIME). The PRIME study is a cohort study of 10,593 middle-aged men undertaken in France and Northern Ireland in the 1990s. A total of 335 incident cases of ischaemic heart disease (IHD) were identified and each case was matched to 2 IHD free controls. Q fever seropositivity was determined using a commercial IgG ELISA method. Results: Seroprevalence of Q fever in the controls from Northern Ireland and France were 7.8% and 9.0% respectively. No association was seen between seropositivity and age, smoking, lipid levels, or inflammatory markers. The unadjusted odds ratio (95% CI) for Q fever seropositivity in cases compared to controls was 0.95 (0.59, 1.57). The relationship was substantially unaltered following adjustment for cardiovascular risk factors and potential confounders. Conclusion: Serological evidence of past infection with C. burnetii was not found to be associated with an increased risk of IHD.
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页数:5
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