Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones

被引：16
|
作者：
Pan, Gao-Fei [1 ]
Su, Li [1 ]
Zhang, Yan-Lei [1 ]
Guo, Shi-Huan [1 ]
Wang, Yong-Qiang [1 ]
机构：
[1] Northwest Univ, Dept Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 30期
基金：
中国国家自然科学基金;
关键词：
AZA-MICHAEL ADDITION; ENANTIOSELECTIVE SYNTHESIS; ANTITUMOR AGENTS; 2-SUBSTITUTED 2,3-DIHYDRO-4-QUINOLONES; QUINOLIZIDINE ALKALOIDS; DERIVATIVES; INDOLIZIDINE; CYCLIZATION; FLAVANONES; CATALYSIS;
D O I：
10.1039/c6ra01247g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient organocatalytic one-pot enantioselective synthesis of (R)-2-aryl-2,3-dihydro-4-quinolones from o-aminoacetophenones and aryl aldehydes has been developed. The approach is characterized by beingmetal free, solvent free and protecting group free. A variety of 2-aryl-2,3-dihydro-4-quinolones could be obtained in good yields up to 99% ee.
引用
收藏
页码：25375 / 25378
页数：4
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