Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey

被引：20

作者：

DiIorio, Michael ^{[1
,2
,3
]}

Kennedy, Kevin ^{[4
]}

Liew, Jean W. ^{[5
]}

Putman, Michael S. ^{[6
]}

Sirotich, Emily ^{[7
]}

Sattui, Sebastian E. ^{[8
]}

Foster, Gary ^{[7
,9
]}

Harrison, Carly ^{[10
]}

Larche, Maggie J. ^{[11
,12
]}

Levine, Mitchell ^{[13
]}

Moni, Tarin T. ^{[14
]}

Thabane, Lehana ^{[13
]}

Bhana, Suleman ^{[15
]}

Costello, Wendy ^{[16
]}

Grainger, Rebecca ^{[17
]}

Machado, Pedro M. ^{[18
,19
]}

Robinson, Philip C. ^{[20
,21
]}

Sufka, Paul ^{[22
]}

Wallace, Zachary S. ^{[2
,23
,24
]}

Yazdany, Jinoos ^{[25
]}

Gore-Massy, Monique ^{[26
]}

Howard, Richard A. ^{[27
]}

Kodhek, More A. ^{[28
]}

Lalonde, Nadine ^{[29
]}

Tomasella, Laura-Ann ^{[30
]}

Wallace, John ^{[31
]}

Akpabio, Akpabio ^{[32
]}

Alpizar-Rodriguez, Deshire ^{[33
]}

Beesley, Richard P. ^{[34
]}

Berenbaum, Francis ^{[35
]}

Bulina, Inita ^{[36
]}

Chock, Eugenia Yupei ^{[37
]}

Conway, Richard ^{[38
]}

Duarte-Garcia, Ali ^{[39
]}

Duff, Eimear ^{[40
]}

Gheita, Tamer A. ^{[41
]}

Graef, Elizabeth R. ^{[42
]}

Hsieh, Evelyn ^{[43
,44
]}

El Kibbi, Lina ^{[45
]}

Liew, David F. L. ^{[46
,47
]}

Lo, Chieh ^{[48
]}

Nudel, Michal ^{[49
]}

Singh, Aman Dev ^{[50
,51
]}

Singh, Jasvinder A. ^{[52
,53
]}

Singh, Namrata ^{[54
]}

Ugarte-Gil, Manuel F. ^{[55
,56
]}

Hausmann, Jonathan S. ^{[57
,58
]}

Simard, Julia F. ^{[59
,60
,61
]}

Sparks, Jeffrey A. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Div Rheumatol Inflammat & Immun, 75 Francis St, Boston, MA 02115 USA

[4] McMaster Univ, Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[5] Boston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA

[6] Med Coll Wisconsin, Div Rheumatol, Milwaukee, WI 53226 USA

[7] McMaster Univ, Med, Hamilton, ON, Canada

[8] Univ Pittsburgh Med Ctr, Div Rheumatol & Clin Immunol, Pittsburgh, PA USA

[9] McMaster Univ, Dept Hlth Res Methods Evidence & Impact HEI, Hamilton, ON, Canada

[10] LupusChat, New York, NY USA

[11] McMaster Univ, Div Clin Immunol, Dept Med, Hamilton, ON, Canada

[12] McMaster Univ, Div Allergy Rheumatol, Dept Med, Hamilton, ON, Canada

[13] McMaster Univ, Dept Hlth Res Methods Evidence & Impact HEI, Fac Hlth Sci, Hamilton, ON, Canada

[14] McMaster Univ, Dept Biochem & Biomed Sci, Fac Sci, Hamilton, ON, Canada

[15] Crystal Run Healthcare, Rheumatol, Middletown, NY USA

[16] Irish Childrens Arthrit Network iCAN, Tipperary, Ireland

[17] Univ Otago Wellington, Dept Med, Wellington, New Zealand

[18] UCL, MRC Ctr Neuromuscular Dis, London, England

[19] UCL, Ctr Rheumatol, Rheumatol, London, England

[20] Univ Queensland, Fac Med, Herston, Qld, Australia

[21] Royal Brisbane & Womans Hosp Hlth Serv Dist, Metro North Hosp & Hlth Serv, Herston, Qld, Australia

[22] HealthPartners, Rheumatol, St Paul, MN USA

[23] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Clin Epidemiol Program, Boston, MA 02114 USA

[24] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Rheumatol Unit, Boston, MA 02114 USA

[25] Univ Calif San Francisco, Med Rheumatol, San Francisco, CA 94143 USA

[26] Lupus Fdn Amer Inc, Washington, DC USA

[27] Spondylitis Assoc Amer, Van Nuys, CA USA

[28] Lupus Fdn Kenya, Nairobi, Kenya

[29] Covid 19 Global Rheumatol Alliance, Patient Board, London, ON, Canada

[30] Arthrit Kids South Africa, Johannesburg, South Africa

[31] Autoinflammatory UK, Rheumatol, Edinburgh, Midlothian, Scotland

[32] Univ Uyo Teaching Hosp, Internal Med, Uyo, Nigeria

[33] Mexican Coll Rheumatol, Res Unit, Coyoacan, Mexico

[34] European Network Childhood Arthrit ENCA, Juvenile Arthrit Res, Tonbridge, England

[35] Sorbonne Univ, Rheumatol, Paris, France

[36] Paul Stradins Clin Univ Hosp, Rheumatol, Riga, Latvia

[37] Yale Sch Med, Sect Rheumatol, New Haven, CT USA

[38] St James Hosp, Dept Rheumatol, Dublin, Ireland

[39] Mayo Clin, Div Rheumatol, Rochester, MN USA

[40] St James Hosp, Rheumatol, Dublin, Ireland

[41] Cairo Univ, Fac Med, Rheumatol & Clin Immunol, Cairo, Egypt

[42] Beth Israel Deaconess Med Ctr, Rheumatol, Boston, MA 02215 USA

[43] Yale Sch Med, Div Rheumatol, New Haven, CT USA

[44] VA Connecticut Healthcare Syst, Rheumatol, West Haven Campus, West Haven, CT USA

[45] Specialized Med Ctr Hosp, Internal Med Dept, Div Rheumatol, Riyadh, Saudi Arabia

[46] Austin Hlth, Rheumatol, Heidelberg West, Vic, Australia

[47] Austin Hlth, Clin Pharmacol & Therapeut, Heidelberg, Vic, Australia

[48] I Shou Univ, Coll Med, Rheumatol, Yanchau Sheng, Taiwan

[49] Israeli Assoc RMDs Patients Mifrakim Tzeirim, Haifa, Israel

[50] Govt Med Coll Amritsar, Dept Community Med, Amritsar, Punjab, India

来源：

RMD OPEN | 2022年 / 8卷 / 02期

关键词：

COVID-19; patient reported outcome measures; inflammation; vaccination;

D O I：

10.1136/rmdopen-2022-002587

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective We investigated prolonged COVID-19 symptom duration, defined as lasting 28 days or longer, among people with systemic autoimmune rheumatic diseases (SARDs). Methods We analysed data from the COVID-19 Global Rheumatology Alliance Vaccine Survey (2 April 2021-15 October 2021) to identify people with SARDs reporting test-confirmed COVID-19. Participants reported COVID-19 severity and symptom duration, sociodemographics and clinical characteristics. We reported the proportion experiencing prolonged symptom duration and investigated associations with baseline characteristics using logistic regression. Results We identified 441 respondents with SARDs and COVID-19 (mean age 48.2 years, 83.7% female, 39.5% rheumatoid arthritis). The median COVID-19 symptom duration was 15 days (IQR 7, 25). Overall, 107 (24.2%) respondents had prolonged symptom duration (>= 28 days); 42/429 (9.8%) reported symptoms lasting >= 90 days. Factors associated with higher odds of prolonged symptom duration included: hospitalisation for COVID-19 vs not hospitalised and mild acute symptoms (age-adjusted OR (aOR) 6.49, 95% CI 3.03 to 14.1), comorbidity count (aOR 1.11 per comorbidity, 95% CI 1.02 to 1.21) and osteoarthritis (aOR 2.11, 95% CI 1.01 to 4.27). COVID-19 onset in 2021 vs June 2020 or earlier was associated with lower odds of prolonged symptom duration (aOR 0.42, 95% CI 0.21 to 0.81). Conclusion Most people with SARDs had complete symptom resolution by day 15 after COVID-19 onset. However, about 1 in 4 experienced COVID-19 symptom duration 28 days or longer; 1 in 10 experienced symptoms 90 days or longer. Future studies are needed to investigate the possible relationships between immunomodulating medications, SARD type/flare, vaccine doses and novel viral variants with prolonged COVID-19 symptoms and other postacute sequelae of COVID-19 among people with SARDs.

引用

页数：12

共 50 条

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