Rhodium-Catalysed Intermolecular Alkyne Hydroacylation: The Enantioselective Synthesis of α- and β-Substituted Ketones by Kinetic Resolution

被引：27
|
作者：
Gonzalez-Rodriguez, Carlos [1 ]
Parsons, Scott R. [1 ]
Thompson, Amber L. [1 ]
Willis, Michael C. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 36期
基金：
英国工程与自然科学研究理事会;
关键词：
homogeneous catalysis; hydroacylation; ketones; kinetic resolution; rhodium; ALDEHYDE OXIDATION LEVEL; INTRAMOLECULAR HYDROACYLATION; C-H; ASYMMETRIC CATALYSIS; ALKENE; 4-PENTENALS; LIGAND; ACTIVATION; EFFICIENT; ALCOHOL;
D O I：
10.1002/chem.201001748
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chemical Equation Presented Cleared up! Intermolecular alkyne hydroacylation represents a new addition to the range of transition- metalcatalysed hydroacylation reactions that can be performed in an enantioselective manner. By using a kinetic resolution procedure, both racemic α- and βsubstituted aldehydes can be converted into the corresponding enantiomerically enriched substituted enone products (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10950 / 10954
页数：5
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