Serum level of anti-mullerian hormone as predictor of ovarian response in IVF

Ovarian reserve assessment and the subsequent ovarian response are one of the most important factors in the evaluation of patients who are about to undergo IVF. Lately, Anti-Mullerian hormone (AMH) has been increasingly used and tested as an endocrine marker for ovarian response. The aim of this study was to evaluate the influence of AMH levels on ovarian response in IVF in order to optimize the treatment of patients with infertility problems. A prospective study was conducted on a sample of 96 women about to undergo the IVF treatment at the Clinical Centre of Vojvodina, Department of Gynecology and Obstetrics in Novi Sad. Based on their AMH levels, the patients were divided into three groups. Group 1- patients whose AMH levels were <=0.6 ng/ml (n=14), group 2 - patients whose AMH levels were 0.6-3.0 ng/ml (n=51) and group 3 - patients whose AMH levels were >3.0 ng/ml (n=30). Group 3 was a high-responder group (the average number of retrieved oocytes during aspiration was 10.70 +/- 7.23 and the average number of retrieved embryos was 6.86 +/- 6.65). The patients from group 1 had the poorest ovarian response (the average number of retrieved oocytes during aspiration was 4.43 +/- 3.10 and the average number of retrieved embryos was 2.79 +/- 2.04), p<0.001. Our results show a strong positive correlation between AMH levels and ovarian response during controlled ovarian hyperstimulation, which makes AMH a very reliable marker for ovarian response.