This study examined the relationships between workplace heterosexism, unsupportive social interactions (negative responses from others concerning one's experience of heterosexism), and adjustment among 97 employed lesbian, gay, and bisexual (LGB) individuals. Results revealed that heterosexism and unsupportive social interactions were each related to negative psychological health outcomes. After controlling for outness and involvement in the LGB community, responses characterized by blaming were found to moderate the relationship between heterosexism and both depression and distress. Contrary to predictions, results suggested that at low levels of blaming there was a positive relationship between heterosexism and both depression and distress. It may be possible that at low levels of blaming, the salient stressor was heterosexism, whereas at high levels of blaming, the salient stressor was the blaming itself.