Synthesis and in vitro insulin-mimetic activities of zinc(II) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

被引：11
|
作者：
Kawarada, Hikaru [1 ]
Yoshikawa, Yutaka [2 ]
Yasui, Hiroyuki [2 ]
Kuwahara, Shunsuke [1 ]
Habata, Yoichi [1 ]
Saito, Ryota [1 ]
机构：
[1] Toho Univ, Dept Chem, Chiba 2748510, Japan
[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Kyoto 6078414, Japan
来源：
METALLOMICS | 2011年 / 3卷 / 07期
关键词：
ALDOSE REDUCTASE INHIBITORS; IDENTIFICATION; BIOCHEMISTRY; ADIPOCYTES; PREVENTION; VANADIUM; AGENTS;
D O I：
10.1039/c1mt00009h
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro4- hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.
引用
收藏
页码：675 / 679
页数：5
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