Cell plasticity in epithelial homeostasis and tumorigenesis

被引：158
|
作者：
Varga, Julia [1 ]
Greten, Florian R. [1 ,2 ,3 ]
机构：
[1] Inst Tumor Biol & Expt Therapy, Georg Speyer Haus,Paul Ehrlich Str 42-44, D-60596 Frankfurt, Germany
[2] German Canc Consortium DKTK, D-69120 Heidelberg, Germany
[3] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 10期
关键词：
CANCER STEM-CELL; NF-KAPPA-B; TO-MESENCHYMAL TRANSITION; COLON-CANCER; STEM/PROGENITOR CELLS; EXTRACELLULAR-MATRIX; PROMOTES METASTASIS; CRYPT HOMEOSTASIS; PROGENITOR CELLS; FEEDBACK LOOP;
D O I：
10.1038/ncb3611
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.
引用
收藏
页码：1133 / 1141
页数：9
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