Sensitization of naive beagles by intradermal injection of an ascaris antigen:: Induction of a model of skin allergy

被引：3
|
作者：
Torres, R.
Grifols, J.
Marco, A.
de Mora, F.
机构：
[1] Univ Autonoma Barcelona, Dept Farmacol, E-08193 Barcelona, Spain
[2] Isoquimen SL, Barcelona, Spain
[3] Univ Autonoma Barcelona, Dept Anim Pathol, E-08193 Barcelona, Spain
来源：
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2006年 / 28卷 / 04期
关键词：
atopic dermatitis; ascaris suum antigen; canine model; intradermal sensitization;
D O I：
10.1080/08923970601067417
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ascaris suum-hypersensitive beagles represent a unique model of skin allergy. Despite its suitability, the need to test numerous dogs prior to the selection of natural positive responders causes many complications. We hypothesized that the model could be induced in adult beagles by primary sensitization. Ten dogs were included in an intradermal sensitization program using ascaris antigen and were thereafter tested for cutaneous reaction. After 2 weeks, 60% developed a positive reaction that lasted for months. We therefore present a straightforward method to establish the Ascaris canine model of allergy that will extend its availability for research in cutaneous allergy immunomodulation.
引用
收藏
页码：697 / 702
页数：6
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