Current treatment options in acute myeloid leukemia

被引：0
|
作者：
Heuser, M. [1 ]
Schlenk, R. F. [2 ]
Ganser, A. [1 ]
机构：
[1] Hannover Med Sch, Klin Hamatol Hamostaseol Onkol & Stammzelltranspl, D-30625 Hannover, Germany
[2] Univ Ulm Klinikum, Innere Med Klin 3, Ulm, Germany
来源：
INTERNIST | 2011年 / 52卷 / 12期
关键词：
Acute myeloid leukemia; WHO classification; Allogeneic stem cell transplantation; Cytogenetics; Molecular genetics; CONVENTIONAL CARE REGIMENS; STEM-CELL TRANSPLANTATION; HIGH-DOSE DAUNORUBICIN; TRANS-RETINOIC ACID; ELDERLY-PATIENTS; OLDER PATIENTS; INTENSIVE CHEMOTHERAPY; COMPLETE REMISSION; PROGNOSTIC IMPACT; IDH2; MUTATIONS;
D O I：
10.1007/s00108-011-2929-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Genetic aberrations form the basis for diagnostic classification of patients with acute myeloid leukemia (AML) according to the World Health Organization (WHO) classification. Moreover, these aberrations predict response to induction chemotherapy, relapse-free survival, and overall survival of patients with AML. Understanding the pathogenetic role of cytogenetic and molecular changes has led to the development of targeted treatment strategies that require rapid diagnostic assessment of the genetic profile of each patient to select the best treatment available.
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收藏
页码：1386 / +
页数：6
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