Selective Synthesis of Functionally Substituted 1,2,3-Triazoles

被引：6
|
作者：
Golobokova, T. V. [1 ]
Proidakov, A. G. [1 ]
Kizhnyaev, V. N. [1 ]
机构：
[1] Irkutsk State Univ, Irkutsk 664003, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 03期
关键词：
1,2,3-triazole; enolate-azide cycloaddition; organic azides; alpha-bromo ketone; regioselectivity; dioxane dibromide; N-bromosuccinimide; 1,4,5-TRISUBSTITUTED 1,2,3-TRIAZOLES; REGIOSPECIFIC SYNTHESIS; CONJUGATES SYNTHESIS; AZIDE CYCLOADDITION; POTENT INHIBITORS; HYBRIDS; DESIGN;
D O I：
10.1134/S1070428020030136
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Different conditions were used to achieve selective formation of 4.5-disubstituted 1-aryl(hetaryl)-1,2,3-triazoles via cycloaddition of the corresponding enolates and aryl or hetaryl azides. Optimal conditions were found for the bromination of 1-(5-methyl-1-phenyl-1,2,3-triazol-4-yl)ethanone to obtain 2-bromo-1-(5-methyl-1-phenyl-1,2,3-triazol-4-yl)ethanone.
引用
收藏
页码：446 / 453
页数：8
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