Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

被引：59

作者：

Fernandez, Lucia ^{[1
]}

Breidenstein, Elena B. M. ^{[1
]}

Song, Diana ^{[1
]}

Hancock, Robert E. W. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V5Z 1M9, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 02期

关键词：

CYSTIC-FIBROSIS; MUTANT LIBRARY; SUSCEPTIBILITY; CIPROFLOXACIN; FLUORESCENS; SEQUENCE; LON;

D O I：

10.1128/AAC.05336-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa possesses complex regulatory networks controlling virulence and survival under adverse conditions, including antibiotic pressure, which are interconnected and share common regulatory proteins. Here, we screen a panel of 13 mutants defective in intracellular proteases and demonstrate that, in addition to the known alterations in Lon and AsrA mutants, mutation of three protease-related proteins PfpI, ClpS, and ClpP differentially affected antibiotic resistance, swarming motility, and biofilm formation.

引用

页码：1128 / 1132

页数：5

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