Role of LFA-1 and ICAM-1 in Cancer

被引：97
|
作者：
Reina, Manuel [1 ,2 ]
Espel, Enric [1 ,2 ]
机构：
[1] Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, Diagonal 643, E-08028 Barcelona, Spain
[2] Univ Barcelona, Fac Biol, Celltec UB, Diagonal 643, E-08028 Barcelona, Spain
来源：
CANCERS | 2017年 / 9卷 / 11期
关键词：
cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment; CHRONIC LYMPHOCYTIC-LEUKEMIA; INTERCELLULAR-ADHESION MOLECULE-1; REGULATORY T-CELLS; TUMOR-ASSOCIATED MACROPHAGES; COLONIC EPITHELIAL-CELLS; MATURE DENDRITIC CELLS; ACTIVATED KILLER-CELLS; UP-REGULATION; BONE-MARROW; CTL RESPONSES;
D O I：
10.3390/cancers9110153
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and alpha(L)beta(2)), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia. Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.
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页数：14
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