Self-assembled micelles based on gambogenic acid-phospholipid complex for sustained-release drug delivery

被引：11
|
作者：
Wang, Beilei [1 ]
Cheng, Weiye [1 ]
Zhang, Caiyun [1 ]
Bao, Youmei [2 ]
Zha, Liqiong [1 ]
Qian, Jiajia [1 ]
Hong, Lufeng [1 ]
Chen, Weidong [1 ]
机构：
[1] Anhui Univ Chinese Med, Coll Pharm, Hefei 230038, Anhui, Peoples R China
[2] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
来源：
JOURNAL OF MICROENCAPSULATION | 2019年 / 36卷 / 06期
基金：
中国国家自然科学基金;
关键词：
GNA; GNA-PLC; GNA-PLC micelles; self-assembly; in vitro release; pharmacokinetic; POLYPRENYLATED XANTHONES; INHIBITS PROLIFERATION; GARCINIA-HANBURYI; A549; CELLS; IN-VITRO; APOPTOSIS; MAPK; DISSOLUTION; STABILITY; SYSTEMS;
D O I：
10.1080/02652048.2019.1656294
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size of the GNA-PLC micelles was 291.23 nm which was approximate agreed with the transmission electron microscopy (TEM). In vitro release profile showed the GNA-PLC and GNA-PLC micelles have significant sustained-release of GNA compared with crude GNA. Pharmacokinetic parameters indicated that the area under concentration-time curve (AUC(0 -> t)) of GNA in cases of GNA-PLC and GNA-PLC micelles are 2.04- and 3.92-fold higher than crude GNA, respectively. Conclusions: The better water solubility and higher bioavailability of GNA in GNA-PLC micelles with significant sustained-release of GNA endow the nanoparticle with great potential in GNA delivery system.
引用
收藏
页码：566 / 575
页数：10
相关论文
共 50 条
  • [1] Self-assembled polyion complex micelles for sustained release of hydrophilic drug
    Yuan, Jinfang
    Luo, Yali
    Gao, Qingyu
    JOURNAL OF MICROENCAPSULATION, 2011, 28 (02) : 93 - 98
  • [2] Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release
    Li, Yang
    Lin, Jinyan
    Yang, Xiangrui
    Li, Yanxiu
    Wu, Shichao
    Huang, Yu
    Ye, Shefang
    Xie, Liya
    Dai, Lizong
    Hou, Zhenqing
    ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (32) : 17573 - 17581
  • [3] Self nanoemulsifying drug delivery system of stabilized ellagic acid-phospholipid complex with improved dissolution and permeability
    Avachat, Amelia M.
    Patel, Vijay G.
    SAUDI PHARMACEUTICAL JOURNAL, 2015, 23 (03) : 276 - 289
  • [4] Self-assembled micelles based on hydrophobically modified quaternized cellulose for drug delivery
    Song, Yongbo
    Zhang, Lingzhi
    Gan, Weiping
    Zhou, Jinping
    Zhang, Lina
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 83 (02) : 313 - 320
  • [5] Preparation of self-assembled nanoparticles of ε-polylysine-sodium alginate: A sustained-release carrier for antigen delivery
    Yuan, Jing
    Guo, Lu
    Wang, Sijia
    Liu, Dan
    Qin, Xia
    Zheng, Lili
    Tian, Chunlian
    Han, Xiaohu
    Chen, Ran
    Yin, Ronghuan
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 171 : 406 - 412
  • [6] Self-Assembled Micelles Based on PEG-Polypeptide Hybrid Copolymers for Drug Delivery
    Hua, Shou-Hu
    Li, Yong-Yong
    Liu, Yun
    Xiao, Wang
    Li, Cao
    Huang, Fu-Wei
    Zhang, Xian-Zheng
    Zhuo, Ren-Xi
    MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (01) : 81 - 86
  • [7] Self-assembled micelles of N-phthaloyl-carboxymethychitosan for drug delivery
    Peng, Xianghong
    Zhang, Lina
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2009, 337 (1-3) : 21 - 25
  • [8] Mixed micelles self-assembled from block copolymers for drug delivery
    Attia, Amalina Bte Ebrahim
    Ong, Zhan Yuin
    Hedrick, James L.
    Lee, Phin Peng
    Ee, Pui Lai Rachel
    Hammond, Paula T.
    Yang, Yi-Yan
    CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2011, 16 (03) : 182 - 194
  • [9] Self-assembled nanoparticles from thermo-sensitive polyion complex micelles for controlled drug release
    Li, Guiying
    Guo, Lei
    Meng, Yanfeng
    Zhang, Ting
    CHEMICAL ENGINEERING JOURNAL, 2011, 174 (01) : 199 - 205
  • [10] Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled β-casein micelles
    Bachar, Michal
    Mandelbaum, Amitai
    Portnaya, Irina
    Perlstein, Hadas
    Even-Chen, Simcha
    Barenholz, Yechezkel
    Danino, Dganit
    JOURNAL OF CONTROLLED RELEASE, 2012, 160 (02) : 164 - 171
12345