Glycogen synthase kinase 3β (GSK3β) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone

被引：42
|
作者：
Maurer, Martin H.
Bromme, Jens O.
Feldmann, Robert E., Jr.
Jarve, Anne
Sabouri, Fatemeh
Burgers, Heinrich F.
Schelshorn, Dominik W.
Kruger, Carola
Schneider, Armin
Kuschinsky, Wolfgang
机构：
[1] Heidelberg Univ, Dept Physiol & Pathophysiol, Div Syst Physiol, D-69120 Heidelberg, Germany
[2] SYGNIS Pharma AG, Heidelberg, Germany
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 03期
关键词：
neural stem cell; neurosphere; Glycogen Synthase Kinase 3 beta; two-dimensional gel electrophoresis; rat; subventricular zone;
D O I：
10.1021/pr0605825
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3 beta (GSK3 beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3 beta inhibition, associated with decreased apoptosis.
引用
收藏
页码：1198 / 1208
页数：11
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