Parietal cells-new perspectives in glomerular disease

被引:21
|
作者
Miesen, Laura [1 ]
Steenbergen, Eric [1 ]
Smeets, Bart [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, RIHS, Dept Pathol,RIMLS, Geert Grootepl 24, NL-6525 GA Nijmegen, Netherlands
关键词
Parietal epithelial cell; Glomerulus; Focal and segmental glomerulosclerosis; Crescentic glomerulonephritis; Podocyte regeneration; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; EPITHELIAL-CELLS; PODOCYTE REGENERATION; EXPRESSION; GLOMERULONEPHRITIS; MICRORNA-193A; PROTEINS; INJURY; MTOR; ACID;
D O I
10.1007/s00441-017-2600-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In normal glomeruli, parietal epithelial cells (PECs) line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells (PTECs) at the urinary pole and with the podocytes at the vascular pole. PECs, PTECs and podocytes have a common mesenchymal origin and are the result of divergent differentiation during embryogenesis. Podocytes and PTECs are highly differentiated cells with well-established functions pertaining to the maintenance of the filtration barrier and transport, respectively. For PECs, no specific function other than a structural one has been known until recently. Possible important functions for PECs in the fate of the glomerulus in glomerular disease have now become apparent: (1) PECs may be involved in the replacement of lost podocytes; (2) PECs form the basis of extracapillary proliferative lesions and subsequent sclerosis in glomerular disease. In addition to the acknowledgement that PECs are crucial in glomerular disease, knowledge has been gained regarding the molecular processes driving the phenotypic changes and behavior of PECs. Understanding these molecular processes is important for the development of specific therapeutic approaches aimed at either stimulation of the regenerative function of PECs or inhibition of the pro-sclerotic action of PECs. In this review, we discuss recent advances pertaining to the role of PECs in glomerular regeneration and disease and address the major molecular processes involved.
引用
收藏
页码:237 / 244
页数:8
相关论文
共 50 条
  • [1] Parietal cells—new perspectives in glomerular disease
    Laura Miesen
    Eric Steenbergen
    Bart Smeets
    Cell and Tissue Research, 2017, 369 : 237 - 244
  • [2] A new function for parietal epithelial cells: a second glomerular barrier
    Ohse, Takamoto
    Chang, Alice M.
    Pippin, Jeffrey W.
    Jarad, George
    Hudkins, Kelly L.
    Alpers, Charles E.
    Miner, Jeffrey H.
    Shankland, Stuart J.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2009, 297 (06) : F1566 - F1574
  • [3] Retinoids Augment the Expression of Podocyte Proteins by Glomerular Parietal Epithelial Cells in Experimental Glomerular Disease
    Zhang, Jiong
    Pippin, Jeffrey W.
    Vaughan, Michael R.
    Krofft, Ronald D.
    Taniguchi, Yoshinori
    Romagnani, Paola
    Nelson, Peter J.
    Liu, Zhi-Hong
    Shankland, Stuart J.
    NEPHRON EXPERIMENTAL NEPHROLOGY, 2012, 121 (1-2): : E23 - E37
  • [4] Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases
    Achenbach, Johannes
    Mengel, Michael
    Tossidou, Irini
    Peters, Imke
    Park, Joon-Keun
    Haubitz, Marion
    Ehrich, Jochen H.
    Haller, Hermann
    Schiffer, Mario
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (10) : 3138 - 3145
  • [5] Circulating Tumor Cells-New Challenges Ahead
    Lianidou, Evi S.
    CLINICAL CHEMISTRY, 2012, 58 (05) : 805 - 807
  • [6] Cells of Renin Lineage Are Progenitors of Podocytes and Parietal Epithelial Cells in Experimental Glomerular Disease
    Pippin, Jeffrey W.
    Sparks, Matthew A.
    Glenn, Sean T.
    Buitrago, Sandra
    Coffman, Thomas M.
    Duffield, Jeremy S.
    Gross, Kenneth W.
    Shankland, Stuart J.
    AMERICAN JOURNAL OF PATHOLOGY, 2013, 183 (02): : 542 - 557
  • [7] GLOMERULAR DISEASE Pre-eclampsia, podocyturia and the role of parietal epithelial cells
    Saritas, Turgay
    Moeller, Marcus J.
    NATURE REVIEWS NEPHROLOGY, 2014, 10 (11) : 615 - 616
  • [8] Atlas of gene expression in the mouse kidney: new features of glomerular parietal cells
    Cheval, Lydie
    Pierrat, Fabien
    Dossat, Carole
    Genete, Mathieu
    Imbert-Teboul, Martine
    Van Huyen, Jean-Paul Duong
    Poulain, Julie
    Wincker, Patrick
    Weissenbach, Jean
    Piquemal, David
    Doucet, Alain
    PHYSIOLOGICAL GENOMICS, 2011, 43 (03) : 161 - 173
  • [9] Transcriptional Landscape of Glomerular Parietal Epithelial Cells
    Gharib, Sina A.
    Pippin, Jeffrey W.
    Ohse, Takamoto
    Pickering, Scott G.
    Krofft, Ronald D.
    Shankland, Stuart J.
    PLOS ONE, 2014, 9 (08):
  • [10] Parietal Epithelial Cells and Podocytes in Glomerular Diseases
    Smeets, Bart
    Moeller, Marcus J.
    SEMINARS IN NEPHROLOGY, 2012, 32 (04) : 357 - 367