In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of dimenhydrinate

被引：15
|
作者：
Leichner, Christina [1 ]
Baus, Randi Angela [1 ]
Jelkmann, Max [1 ]
Plautz, Melanie [1 ]
Barthelmes, Jan [1 ]
Duennhaupt, Sarah [1 ]
Bernkop-Schnuerch, Andreas [1 ]
机构：
[1] Univ Innsbruck, Ctr Chem & Biomed, Dept Pharmaceut Technol, Inst Pharm, Innrain 80-82, A-6020 Innsbruck, Austria
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2019年 / 9卷 / 05期
关键词：
Self-emulsifying drug delivery systems; Nasal administration; Emulsion; Dimenhydrinate; Permeation; EMULSIFICATION; PERMEABILITY; MUCOADHESIVE; FORMULATION; TRANSPORT;
D O I：
10.1007/s13346-019-00634-1
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
The objective of the study was the development and in vitro characterization of a self-emulsifying drug delivery system (SEDDS) for the nasal application of dimenhydrinate. Final composition of SEDDS was established based on drug solubility and stability studies. Dimenhydrinate was loaded into the SEDDS pre-concentrates to 7.5% (m/v). The droplet size of the final SEDDS formulations was in a range between 60 and 220 nm. Permeability, as well as tissue toxicity, of the formulations was investigated using bovine nasal mucosa. Enhancement in permeation up to 2.8-fold compared to pure dimenhydrinate was confirmed. Furthermore, toxicity studies did not reveal any serious tissue damages related to the SEDDS. Additionally, irritation potential of SEDDS was evaluated in ciliary beat frequency measurements. Incorporation of dimenhydrinate into SEDDS might therefore be considered as a promising approach within the field of nasal delivery of antiemetics by utilizing permeation enhancement strategy.
引用
收藏
页码：945 / 955
页数：11
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