New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

被引：286
|
作者：
Waterhouse, Emily G. [1 ]
Xu, Baoji [1 ]
机构：
[1] Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20057 USA
来源：
MOLECULAR AND CELLULAR NEUROSCIENCE | 2009年 / 42卷 / 02期
基金：
美国国家卫生研究院;
关键词：
LONG-TERM POTENTIATION; LOCAL PROTEIN-SYNTHESIS; MESSENGER-RNA TRANSPORT; HIGH-FREQUENCY STIMULATION; PEPTIDE-CHAIN ELONGATION; DEPENDENT TRANSLATION; HIPPOCAMPAL-NEURONS; SPINE MORPHOLOGY; MAMMALIAN TARGET; REGULATORY MECHANISMS;
D O I：
10.1016/j.mcn.2009.06.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Substantial evidence indicates that brain-derived neurotrophic factor (BDNF) plays a crucial role in synaptic plasticity. Long-lasting synaptic plasticity is restricted to active synapses and requires new protein synthesis. Recent work. has identified local protein synthesis as an important source for new protein during the expression of enduring synaptic plasticity. This review discusses recent progress in understanding the mechanisms that restrict the action of BDNF to active synapses and by which BDNF mediates chemical and structural modifications of individual synapses, placing an emphasis on the role of local protein synthesis in these processes. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 89
页数：9
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