ADDRESSING AND ADVANCING THE PROBLEM OF MISSING DATA

被引:6
|
作者
Walton, Marc K. [1 ]
机构
[1] US FDA, Off Translat Sci, CDER, Silver Spring, MD 20993 USA
关键词
Missing data; Imputation; Prevention; Sensitivity analysis; MULTIPLE IMPUTATION; TRIAL;
D O I
10.1080/10543400903238959
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Missing data can pose substantial risk of reaching incorrect conclusions from clinical studies. Imputation for the missing values is common, but can supply only an approximate result desired to be "close enough" to the intended true result. Prevention optimally addresses the issue. Knowledge of the effective techniques to minimize the problem, likely to vary with clinical setting, is presently inadequate. Formal evaluation of preventative methods should be encouraged and lead to publication of the assessments. Designers of clinical trials should also plan for study analysis where missing values occur. Simple imputation methods have been used and may be sufficient in some settings, but have potential to introduce bias and inaccuracy into the statistical analysis. More complex methods such as multiple imputation potentially offer reduced risk of bias. Multiple imputation also offers the potential for study designers to include some auxiliary outcome assessments that may substantially improve the quality of the imputation with limited added burden to the study. In all cases, sensitivity analyses examining the importance of the specific preferred method as compared to methods with different underlying assumptions is essential to assessing how adequately the missing data issue has been addressed.
引用
收藏
页码:945 / 956
页数:12
相关论文
共 50 条
  • [1] Addressing the problem of missing data in decision tree modeling
    Haji-Maghsoudi, Saiedeh
    Rastegari, Azam
    Garrusi, Behshid
    Baneshi, Mohammad Reza
    JOURNAL OF APPLIED STATISTICS, 2018, 45 (03) : 547 - 557
  • [2] Addressing Missing Data in Clinical Trials
    van der Laan, Mark
    Lorenz, Todd J.
    ANNALS OF INTERNAL MEDICINE, 2011, 155 (02) : 135 - 135
  • [3] Addressing Missing Data in Clinical Trials
    Fleming, Thomas R.
    ANNALS OF INTERNAL MEDICINE, 2011, 154 (02) : 113 - +
  • [4] Advancing theory by addressing the Gender Data Gap
    不详
    EUROPEAN MANAGEMENT JOURNAL, 2022, 40 (03) : 307 - 309
  • [5] Addressing the Challenges of Missing Data in Anthropological Networks
    Ready, Elspeth
    Hazel, Ashley
    Jones, James Holland
    AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2018, 165 : 221 - 221
  • [6] Addressing the Missing Instructional Data Problem: Using a Teacher Log to Document Tier 1 Instruction
    Kurz, Alexander
    Elliott, Stephen N.
    Roach, Andrew T.
    REMEDIAL AND SPECIAL EDUCATION, 2015, 36 (06) : 361 - 373
  • [7] Addressing the Missing Heritability Problem With the Help of Regulatory Features
    Dong, Shan-Shan
    Guo, Yan
    Yang, Tie-Lin
    EVOLUTIONARY BIOINFORMATICS, 2019, 15
  • [8] Addressing missing data for diagnostic and prognostic purposes
    Loukopoulos P.
    Zolkiewski G.
    Bennett I.
    Sampath S.
    Pilidis P.
    Duan F.
    Mba D.
    Lecture Notes in Mechanical Engineering, 2017, 0 (9783319622736): : 197 - 205
  • [9] Missing data, part 1. Why missing data are a problem
    Tra My Pham
    Pandis, Nikolaos
    White, Ian R.
    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2022, 161 (06) : 888 - 889
  • [10] Methods for addressing missing data in psychiatric and developmental research
    Croy, CD
    Novins, DK
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2005, 44 (12): : 1230 - 1240