Thrombolysis for Acute Ischemic Stroke

被引：9
|
作者：
Uyttenboogaart, M. [1 ]
De Keyser, J. [1 ,2 ]
Luijckx, G. J. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, NL-9700 RB Groningen, Netherlands
[2] Vrije Univ Brussels, Univ Ziekenhuis Brussel, Dept Neurol, Brussels, Belgium
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 14期
关键词：
TISSUE-PLASMINOGEN ACTIVATOR; RANDOMIZED CONTROLLED-TRIAL; CEREBRAL-ARTERY STROKE; INTRAVENOUS THROMBOLYSIS; TIME WINDOW; INTERVENTIONAL MANAGEMENT; INTRACEREBRAL HEMORRHAGE; TPA THERAPY; H; ALTEPLASE;
D O I：
10.2174/156802609789869655
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the last decennium, thrombolytic therapy has changed the management of acute ischemic stroke. Randomized clinical studies have demonstrated that intravenous thrombolysis with tissue plasminogen activator improves functional outcomes. Recently the time window for intravenous thrombolysis has been extended from 3 to 4.5 hours after stroke onset, which will allow more stroke patients to benefit from this treatment. Currently several studies are investigating how to improve recanalization rates of thrombolytic therapy. In this review several aspects of intravenous and intra-arterial thrombolysis are discussed.
引用
收藏
页码：1285 / 1290
页数：6
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