SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)

被引：46
|
作者：
Lawler, S [1 ]
Cuenda, A [1 ]
Goedert, M [1 ]
Cohen, P [1 ]
机构：
[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
来源：
FEBS LETTERS | 1997年 / 414卷 / 01期
基金：
英国医学研究理事会;
关键词：
SAPK; JNK; p38; MAP kinase; cytokine; stress;
D O I：
10.1016/S0014-5793(97)00990-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A cDNA was cloned and expressed that encodes human stress-activated protein kinase kinase-4 (SKK4), a novel MAP kinase kinase family member whose mRNA is widely expressed in human tissues. SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38 beta, SAPK3/ERK6 or SAPK4, It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila. In human epithelial KB cells SKK4 and SKK1/MKK4 (another activator of SAPK1/JNK) were both activated by stressful stimuli, but only SKK4 was activated by proinflammatory cytokines, The identification of SKK4 explains why the major SAPK1/JNK activator detected in many mammalian cell extracts is chromatographically separable from SKK1/MKK4. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：153 / 158
页数：6
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