One-pot synthesis of carbamates and thiocarbamates from Boc-protected amines

被引：24
|
作者：
Kim, Hee-Kwon [1 ,2 ]
Lee, Anna [3 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Chonbuk Natl Univ, Med Sch & Hosp, Biomed Res Inst, Dept Nucl Med,Mol Imaging & Therapeut Med Res Ctr, Jeonju 54907, Jeonbuk, South Korea
[3] Myongji Univ, Dept Chem, Yongin 17058, South Korea
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 44期
基金：
新加坡国家研究基金会;
关键词：
One-pot synthesis; Carbamates; Thiocarbamates; Isocyanate intermediates; SELECTIVE CARBONYLATION ROUTES; HYDROXAMIC ACIDS; LOSSEN REARRANGEMENTS; UREAS;
D O I：
10.1016/j.tetlet.2016.09.038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient one-pot procedure for the synthesis of carbamates and thiocarbamates has been described. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, the isocyanate intermediates were generated in situ for further reactions with alcohols and thiols to afford the desired carbamates and thiocarbamates in high yields. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4890 / 4892
页数：3
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