Trisnor-Euphane-Type Triterpenoid and Other Constituents Isolated from Euphorbia tanquahuete Sesse & Moc.: Preparation and Cytotoxic Evaluation of Semisynthetic Derivatives of Euphol

被引：4

作者：

Romero-Moran, Luis J. ^{[1
]}

Teresa Ramirez-Apan, Maria ^{[1
]}

Hernandez-Ortega, Simon ^{[1
]}

Martinez-Otero, Diego ^{[2
]}

Delgado, Guillermo ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico

[2] Ctr Conjunto Invest Quim Sustentable UAEM UNAM, Toluca 50200, Mexico

来源：

ACS OMEGA | 2022年 / 7卷 / 39期

关键词：

PLANTS; NMR; SPECTRA;

D O I：

10.1021/acsomega.2c03963

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The natural compound 25,26,27-trisnor-3P-hydroxy-euphan-24-al (1) was isolated for the first time from the bioactive extract of the leaves of Euphorbia tanquahuete, together with the known compounds euphol, eupha-8,23-dien-3P,25-diol, lupeol, cycloeucalenol, P-sitosterol, squalene, and 1-octacosanol. The structure of the new compound was elucidated based on extensive analysis of spectroscopic data and by semisynthesis from euphol. The chemical modification of the alcohol at C3 and the side chain of euphol afforded seven derivatives (6-12). The cytotoxic activity of the natural and semisynthetic compounds evaluated against a panel of human cancer cell lines showed selectivity for certain cell lines and indicated that natural compound 1 and semisynthetic 8 were the most active against leukemia (K562) cell line.

引用

页码：35077 / 35082

页数：6