A visible light-mediated three-component strategy based on the ring-opening of cyclic ethers with aryldiazoacetates and nucleophiles

被引：27
|
作者：
Stivanin, Mateus L. [1 ]
Gallo, Rafael D. C. [1 ]
Spadeto, Joao Paulo M. [1 ]
Cormanich, Rodrigo A. [1 ]
Jurberg, Igor D. [1 ]
机构：
[1] Univ Estadual Campinas, Inst Chem, Rua Monteiro Lobato 270, BR-13083862 Campinas, SP, Brazil
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
MULTICOMPONENT REACTIONS; EQUILIBRIUM ACIDITIES; CHEMISTRY; ESTERS;
D O I：
10.1039/d1qo01780b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A blue light-promoted reaction between aryldiazoacetates and different nucleophiles has been developed in the presence of THF (and other cyclic ethers) as the solvent, allowing the incorporation of these three elements into a single product. Formally, this transformation represents an O-H insertion strategy of more complex alcohols into aryldiazoesters, without the need of pre-assembling them. The method is mild and efficient and proceeds in the absence of metals, generally at room temperature.
引用
收藏
页码：1321 / 1326
页数：6
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