The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives

被引：30

作者：

Weber, Christopher J. ^{[1
]}

Carrillo, Maria C. ^{[1
]}

Jagust, William ^{[2
,3
]}

Jack, Clifford R., Jr. ^{[4
]}

Shaw, Leslie M. ^{[5
]}

Trojanowski, John Q. ^{[6
]}

Saykin, Andrew J. ^{[7
,8
]}

Beckett, Laurel A. ^{[9
]}

Sur, Cyrille ^{[10
]}

Rao, Naren P. ^{[11
]}

Mendez, Patricio Chrem ^{[12
]}

Black, Sandra E. ^{[13
,14
]}

Li, Kuncheng ^{[15
]}

Iwatsubo, Takeshi ^{[16
]}

Chang, Chiung-Chih ^{[17
]}

Sosa, Ana Luisa ^{[18
]}

Rowe, Christopher C. ^{[19
,20
]}

Perrin, Richard J. ^{[21
]}

Morris, John C. ^{[22
]}

Healan, Amanda M. B.

Hall, Stephen E. ^{[1
]}

Weiner, Michael W. ^{[23
]}

机构：

[1] Alzheimers Assoc, Chicago, IL USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[4] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[5] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Alzheimers Dis Core Ctr, Udall Parkinsons Res Ctr,Dept Pathol & Lab Med,In, Philadelphia, PA 19104 USA

[7] Indiana Univ, Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

[8] Indiana Univ, Sch Med, Indiana Alzheimers Dis Res Ctr, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[9] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA

[10] Merck Res Labs, Kenilworth, NJ USA

[11] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru, Karnataka, India

[12] FLENIMontaneses, Ctr Memoria, C1428AQK, RA-2325 Buenos Aires, Argentina

[13] Univ Toronto, Sunnybrook Res Inst, Hurvitz Brain Sci Program, Canadian Partnership Stroke Recovery,Dept Med Neu, Toronto, ON, Canada

[14] Univ Toronto, Sunnybrook Res Inst, LC Campbell Cognit Neurol Res Unit, Hurvitz Brain Sci Res Program, Toronto, ON, Canada

[15] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China

[16] Univ Tokyo, Grad Sch Med, Dept Neuropathol, Tokyo, Japan

[17] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Dept Gen Neurol,Coll Med, Kaohsiung, Taiwan

[18] Natl Inst Neurol & Neurosurg Mexico, Mexico City, Mexico, Mexico

[19] Univ Melbourne, Austin Hlth, Dept Mol Imaging & Therapy, Melbourne, Vic, Australia

[20] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Melbourne, Vic, Australia

[21] Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimer Dis Res Ctr, Dept Pathol & Immunol,Dept Neurol, St Louis, MO USA

[22] Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimer Dis Res Ctr, Dept Neurol, St Louis, MO USA

[23] Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Dept Vet AffairsMed Ctr, Dept Radiol,Dept Med,Dept Psychiat,Dept Neurol, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2021年 / 7卷 / 01期

基金：

加拿大健康研究院; 英国医学研究理事会; 芬兰科学院;

关键词：

Alzheimer's disease; amyloid; biomarkers; cerebrospinal fluid; cognitive impairment; MRI; neuroimaging; PET; Tau; COGNITIVE IMPAIRMENT; BIOMARKER; ACCUMULATION; PARTICIPANTS; DEPOSITION; PROGRESS; PROFILE; CORE; TAU;

D O I：

10.1002/trc2.12226

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Worldwide Alzheimer's Disease Neuroimaging Initiative (WW-ADNI) is a collaborative effort to investigate imaging and biofluid markers that can inform Alzheimer's disease treatment trials. It is a public-private partnership that spans North America, Argentina, Australia, Canada, China, Japan, Korea, Mexico, and Taiwan. In 2004, ADNI researchers began a naturalistic, longitudinal study that continues today around the globe. Through several successive phases (ADNI-1, ADNI-GO, ADNI-2, and ADNI-3), the study has fueled amyloid and tau phenotyping and refined neuroimaging methodologies. WW-ADNI researchers have successfully standardized analyses and openly share data without embargo, providing a rich data set for other investigators. On August 26, 2020, the Alzheimer's Association convened WW-ADNI researchers who shared updates from ADNI-3 and their vision for ADNI-4.

引用

页数：9

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