The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and selectivity

被引：17
|
作者：
Zhou, Ruqiao [1 ,2 ]
Cui, Guiling [3 ]
Qi, Qingrong [3 ]
Huang, Wencai [4 ]
Yang, Li [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, Sch Chem Engn, Chengdu 610065, Peoples R China
来源：
ANALYST | 2020年 / 145卷 / 06期
关键词：
LIVING CELLS; H2S; WATER; RED;
D O I：
10.1039/c9an02323b
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Hydrogen sulfide (H2S), a well-known poisonous gas, has been recognized as a critical endogenous gas transmitter in the past decade. To provide a quick and efficient detection method for hydrogen sulfide, a novel fluorescent probe DCI-NCN was designed based on an isophoronitrile scaffold featured with the cyanoxy group as the detection group. DCI-NCN shows promising results including high selectivity, high sensitivity, good linear relationship and pH stability in vitro. In addition, good biosystem imaging performance of DCI-NCN is observed in Kunming mice.
引用
收藏
页码：2305 / 2310
页数：6
相关论文
共 50 条
  • [1] Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection
    Zhou, Yingzhu
    Mazur, Federico
    Liang, Kang
    Chandrawati, Rona
    [J]. CHEMISTRY-AN ASIAN JOURNAL, 2022, 17 (05)
  • [2] A Novel Fluorescent Probe for Detection of Hydrogen Sulfide and Its Bioimaging Applications in Living Cells
    Zhu, Lei
    Liao, Wenhao
    Chang, Haizhen
    Liu, Xianjun
    Miao, Shaobin
    [J]. CHEMISTRYSELECT, 2020, 5 (02): : 829 - 833
  • [3] Fluorescent probes for hydrogen sulfide detection and bioimaging
    Yu, Fabiao
    Han, Xiaoyue
    Chen, Lingxin
    [J]. CHEMICAL COMMUNICATIONS, 2014, 50 (82) : 12234 - 12249
  • [4] A ratiometric fluorescent probe for sensitive and selective detection of hydrogen sulfide and its application for bioimaging
    Zhang, Caihong
    Zhang, Guomei
    Feng, Liheng
    Li, Junfen
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2015, 216 : 412 - 417
  • [5] Perylenequinone-based "turn on" fluorescent probe for hydrogen sulfide with high sensitivity in living cells
    Chen, Ju-Peng
    Duan, Yi-Meng
    Zheng, Wen-Jun
    Zhang, Qi
    Zong, Qianshou
    Chen, Shaojin
    Wang, Kun-Peng
    Hu, Zhi-Qiang
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2019, 218 : 206 - 212
  • [6] A "turn-on" fluorescent probe with high selectivity and large stokes shift for the detection of hydrogen peroxide and its bioimaging applications
    Hua, Yun
    Shang, Yajing
    Gao, Mengjiao
    Li, Jin
    Kang, Yanfei
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2022, 265
  • [7] Enhanced fluorescent probe with high selectivity and sensitivity to hypochlorous acid
    Fang Fang
    Meixia Tan
    Yihua Zhang
    Lifen Chen
    Houzheng Chen
    Mei Lin
    Fang Ke
    [J]. Chemical Papers, 2023, 77 : 2309 - 2315
  • [8] Enhanced fluorescent probe with high selectivity and sensitivity to hypochlorous acid
    Fang, Fang
    Tan, Meixia
    Zhang, Yihua
    Chen, Lifen
    Chen, Houzheng
    Lin, Mei
    Ke, Fang
    [J]. CHEMICAL PAPERS, 2023, 77 (04) : 2309 - 2315
  • [9] A photostable fluorescent probe based on PET off for the detection of hydrogen sulfide and its application in bioimaging
    Yang, Jialu
    Yin, Caixia
    Wen, Ying
    Zhang, Yongbin
    Huo, Fangjun
    [J]. NEW JOURNAL OF CHEMISTRY, 2020, 44 (17) : 7091 - 7095
  • [10] A human serum albumin-binding-based fluorescent probe for monitoring hydrogen sulfide and bioimaging
    Guo, Meng-Ya
    Liu, Xiao-Jing
    Li, Yun-Zhang
    Wang, Bao-Zhong
    Yang, Yu-Shun
    Zhu, Hai-Liang
    [J]. ANALYST, 2024, 149 (04) : 1280 - 1288
12345