Dendritic cells and lymphoma cells: come together right now

In this issue of Blood, Kolstad et al report an elegantly designed and well-implemented study showing that intratumoral injection of ex vivo-produced immature dendritic cells (DCs), granulocyte macrophage colony-stimulating factor (GM-CSF), and low-dose rituximab into an irradiated tumor elicits objective responses at untreated sites and that these clinical remissions correlate with the induction of tumor-reactive CD8 T-cell responses. © 2015 by The American Society of Hematology.