CHIRAL PHOSPHORIC ACID CATALYZED ASYMMETRIC FRIEDEL-CRAFTS ALKYLATION OF INDOLES WITH NITROOLEFINS

被引：9
|
作者：
Tang, Hong-Ying [1 ]
Zhang, Zhong-Biao [1 ]
机构：
[1] Tianjin Normal Univ, Tianjin Key Lab Water Environm & Resources, Tianjin 300387, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 10期
关键词：
Asymmetric Friedel-Crafts alkylations; enantioselectivities; chiral phosphoric acid; indoles; nitroolefins; TETRAHYDRO-BETA-CARBOLINES; BOND-FORMING REACTIONS; BRONSTED ACID; ENANTIOSELECTIVE ADDITION; NITROALKENES; COMPLEXES; IMINES; ORGANOCATALYSTS; BIS(OXAZOLINE); DISCOVERY;
D O I：
10.1080/10426507.2010.536189
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Asymmetric Michael-type Friedel-Crafts (F-C) alkylations of indoles with nitroolefins catalyzed by a chiral H-8-BINOL-based phosphoric acid were investigated. The reactions took place very smoothly in the presence of only 5 mol-% of catalyst at room temperature to afford the desired F-C alkylation products in good yields and with moderate enantioselectivities.
引用
收藏
页码：2038 / 2046
页数：9
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