Intramolecular Huisgen [3+2] cycloaddition in water: synthesis of fused pyrrolidine-triazoles

被引：12
|
作者：
Kumar, Indresh [1 ]
Mir, Nisar A. [1 ]
Rode, Chandrashaker V. [2 ]
Wakhloo, Basant P. [3 ]
机构：
[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India
[2] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India
[3] Indian Inst Integrat Med, Instrumentat Div, IIIM CSIR Lab, Jammu 180001, Jammu & Kashmir, India
来源：
TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 3-4期
关键词：
GLYCOSIDASE INHIBITORS; GLYCOGEN-PHOSPHORYLASE; BIOLOGICAL EVALUATION; STRUCTURALLY DIVERSE; BETA-GLYCOSIDASES; CLICK-CHEMISTRY; COPPER; 1,2,3-TRIAZOLES; ALKYNES; MECHANISMS;
D O I：
10.1016/j.tetasy.2012.02.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The intramolecular alkyne-azide Huisgen [3+2] cycloaddition reaction as a 'click-chemistry' reaction without a metal catalyst has been studied under aerobic conditions. The synthesis of various pyrrolidine-triazole hybrid compounds has also been achieved by using this intramolecular cycloaddition reaction in water with complete 1,5-regioselectivity. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：225 / 229
页数：5
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