Lennox-Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a severe form of epilepsy associated with intractable seizures and impaired cognition. On inter-ictal electroencephalography (EEG), LGS is characterized by generalized epileptiform discharges including slow (1.5-2.5 Hz) spike-andwave complexes and bursts of paroxysmal fast activity. Onset typically occurs between the ages of 2 and 8 and affects predominantly males. Aetiologies underlying LGS vary widely across patients, and include both genetic and acquired causes (e.g., diffuse brain damage following asphyxia, tuberous sclerosis, encephalitis or metabolic disorders). Prevalence varies between 1-10% of all childhood epilepsy. In 15-20% of patients, the cause of LGS remains unknown. Around 20% of patients develop LGS following infantile West syndrome.