Isoleucine-Catalyzed Direct Asymmetric Aldol Addition of Enolizable Aldehydes

被引：32
|
作者：
Rohr, Kerstin [1 ]
Mahrwald, Rainer [1 ]
机构：
[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 08期
关键词：
ACYCLIC AMINO-ACIDS; ENAMINE CATALYSIS; PROLINE; ENANTIOSELECTIVITY; ORGANOCATALYSIS;
D O I：
10.1021/ol300754n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.
引用
收藏
页码：2180 / 2183
页数：4
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