Farnesol increases the activity of echinocandins against Candida auris biofilms

被引：33
|
作者：
Nagy, Fruzsina [1 ]
Toth, Zoltan [1 ]
Daroczi, Lajos [2 ]
Szekely, Adrien [3 ]
Borman, Andrew M. [3 ]
Majoros, Laszlo [1 ]
Kovacs, Renato [1 ,4 ]
机构：
[1] Univ Debrecen, Fac Med, Dept Med Microbiol, Nagyerdei Krt 98, H-4032 Debrecen, Hungary
[2] Univ Debrecen, Fac Sci & Technol, Dept Solid State Phys, Debrecen, Hungary
[3] Publ Hlth England, UK Natl Mycol Reference Lab, Bristol, Avon, England
[4] Univ Debrecen, Fac Pharm, Nagyerdei Krt 98, H-4032 Debrecen, Hungary
来源：
MEDICAL MYCOLOGY | 2020年 / 58卷 / 03期
关键词：
Candida auris; biofilm; synergy; farnesol; lock therapy; MICAFUNGIN; CASPOFUNGIN; APOPTOSIS;
D O I：
10.1093/mmy/myz057
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Candida auris biofilms exhibit decreased susceptibility to echinocandins, which is associated with poorer clinical outcomes. Farnesol is a quorum-sensing molecule enhancing the activity of antifungals; therefore, we evaluated the in vitro effect of farnesol with anidulafungin, caspofungin, or micafungin against biofilms using fractional inhibitory concentration indexes (FICI), Bliss independence model, LIVE/DEAD-assay and scanning electron microscopy. Based on mathematical models, farnesol caused synergism in eleven out of twelve cases (FICIs range 0.133-0.507; Bliss synergy volume range 70.39-204.6 mu M-2%). This was confirmed by microscope images of combination-exposed biofilms. Our study showed the prominent effect of farnesol with echinocandins against C. auris biofilms.
引用
收藏
页码：404 / 407
页数：4
相关论文
共 50 条
  • [1] Colistin interacts synergistically with echinocandins against Candida auris
    Bidaud, A. L.
    Djenontin, E.
    Botterel, F.
    Chowdhary, A.
    Dannaoui, E.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2020, 55 (03)
  • [2] In Vitro Synergistic Interactions of Isavuconazole and Echinocandins against Candida auris
    Caballero, Unai
    Kim, Sarah
    Eraso, Elena
    Quindos, Guillermo
    Vozmediano, Valvanera
    Schmidt, Stephan
    Jauregizar, Nerea
    [J]. ANTIBIOTICS-BASEL, 2021, 10 (04):
  • [3] Comparative transcriptional analysis of Candida auris biofilms following farnesol and tyrosol treatment
    Jakab, Agnes
    Kovacs, Fruzsina
    Balla, Noemi
    Nagy-Koteles, Csaba
    Ragyak, Agota
    Nagy, Fruzsina
    Borman, Andrew M.
    Majoros, Laszlo
    Kovacs, Renato
    [J]. MICROBIOLOGY SPECTRUM, 2024, 12 (04):
  • [4] PK/PD modeling and simulation of the in vitro activity of the combinations of isavuconazole with echinocandins against Candida auris
    Caballero, Unai
    Eraso, Elena
    Quindos, Guillermo
    Vozmediano, Valvanera
    Schmidt, Stephan
    Jauregizar, Nerea
    [J]. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2023, 12 (06): : 770 - 782
  • [5] Activity of chlorhexidine acetate in combination with fluconazole against suspensions and biofilms of Candida auris
    Hao, Weifeng
    Wang, Yaxian
    Xi, Yue
    Yang, Zhe
    Zhang, Heyu
    Ge, Xuejun
    [J]. JOURNAL OF INFECTION AND CHEMOTHERAPY, 2022, 28 (01) : 29 - 34
  • [6] In vitro assessment of the antifungal and paradoxical activity of different echinocandins against Candida tropicalis biofilms
    Ku, Tsun Sheng N.
    Bernardo, Stella M.
    Lee, Samuel A.
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2011, 60 (11) : 1708 - 1710
  • [7] Photodynamic Therapy Is Effective Against Candida auris Biofilms
    Bapat, Priyanka S.
    Nobile, Clarissa J.
    [J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11
  • [8] The comparative efficacy of antiseptics against Candida auris biofilms
    Kean, Ryan
    McKloud, Emily
    Townsend, Eleanor M.
    Sherry, Leighann
    Delaney, Christopher
    Jones, Brian L.
    Williams, Craig
    Ramage, Gordon
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2018, 52 (05) : 673 - 677
  • [9] In vitro activity of echinocandins against mature biofilms of common and uncommon Candida bloodstream isolates
    Simitsopoulou, M.
    Chatzimoschou, A.
    Tasina, E.
    Georgiadou, E.
    Katragkou, A.
    Roilides, E.
    [J]. MYCOSES, 2012, 55 : 111 - 112
  • [10] In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris
    Nagy, Fruzsina
    Vitalis, Eszter
    Jakab, Agnes
    Borman, Andrew M.
    Forgacs, Lajos
    Toth, Zoltan
    Majoros, Laszlo
    Kovacs, Renato
    [J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
12345