PKC-θ function at the immunological synapse: prospects for therapeutic targeting

被引:60
|
作者
Zanin-Zhorov, Alexandra [3 ]
Dustin, Michael L. [3 ]
Blazar, Bruce R. [1 ,2 ]
机构
[1] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA
[3] NYU, Sch Med, Mol Pathogenesis Program,Skirball Inst Biomol Med, Helen & Martin Kimmel Ctr Biol & Med,Dept Pathol, New York, NY 10016 USA
关键词
KINASE-C-THETA; REGULATORY T-CELLS; NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IN-VIVO; TRANSCRIPTION FACTOR; DEFICIENT MICE; ACTIVATION; RECEPTOR; RESPONSES;
D O I
10.1016/j.it.2011.04.007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Protein kinase C (PKC)-theta regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-theta in T cells is complex. PKC-theta plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-theta is required for the development of natural CD4(+)Foxp3(+) regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-theta in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-theta in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.
引用
收藏
页码:358 / 363
页数:6
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