Chemokines in eosinophil-associated gastrointestinal disorders

被引：21
|
作者：
Hogan, SP [1 ]
Rothenberg, ME [1 ]
Forbes, E [1 ]
Smart, VE [1 ]
Matthaei, KI [1 ]
Foster, PS [1 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Div Mol Biosci, Canberra, ACT 0200, Australia
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2004年 / 4卷 / 01期
关键词：
D O I：
10.1007/s11882-004-0047-8
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte, recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
引用
收藏
页码：74 / 82
页数：9
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