Exploring the interaction of L-cysteine capped CuS nanoparticles with bovine serum albumin (BSA): a spectroscopic study

被引：52
|
作者：
Prasanth, S. [1 ]
Raj, D. Rithesh [1 ]
Vineeshkumar, T. V. [1 ]
Thomas, Riju K. [1 ]
Sudarsanakumar, C. [1 ]
机构：
[1] Mahatma Gandhi Univ, Sch Pure & Appl Phys, Kottayam 686560, Kerala, India
来源：
RSC ADVANCES | 2016年 / 6卷 / 63期
关键词：
COPPER SULFIDE; GOLD NANOPARTICLES; QUANTUM DOTS; PROTEIN; IR; ADSORPTION; BINDING; RAMAN;
D O I：
10.1039/c6ra03583c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions between nanoparticles and proteins have prime importance in nanomedicine and nanotoxicology. L-Cysteine capped copper sulfide (Cy-CuS) nanoparticles having average particle size of 6 nm have been synthesized using chemical coprecipitation method and their interactions with Bovine Serum Albumin (BSA) were explored using various spectroscopic techniques. A ground state complex is formed between BSA and Cy-CuS nanoparticles in solution. The number of binding sites, binding constant, quenching constant and the binding distance between Cy-CuS nanoparticles and BSA were determined. The overall conformation of BSA in the complex was unaltered, however the a-helical content of BSA was marginally reduced.
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页码：58288 / 58295
页数：8
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