Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the 2004-2005 and 2006-2007 epidemics

被引：17

作者：

Jian, Jhih-Wei ^{[1
]}

Lai, Cheng-Tsung ^{[1
]}

Kuo, Chuan-Yi ^{[1
]}

Kuo, Steve Hsu-Sung ^{[1
]}

Hsu, Li-Ching ^{[1
]}

Chen, Pei-Jer ^{[2
]}

Wu, Ho-Sheng ^{[1
,3
]}

Liu, Ming-Tsan ^{[1
]}

机构：

[1] Natl Influenza Ctr, Ctr Dis Control, Taipei 115, Taiwan

[2] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan

[3] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Taipei, Taiwan

来源：

VIRUS RESEARCH | 2008年 / 131卷 / 02期

关键词：

influenza B virus; genetic analysis; evolution;

D O I：

10.1016/j.virusres.2007.09.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza B viruses were predominant in Taiwan during the 2004-2005 epidemic and both Victoria and Yamagata lineage viruses co-circulated. A reassortant influenza B virus that contained a Victoria lineage hemagglutinin (HA) gene and Yamagata lineage neuraminidase (NA) gene appeared first in 2002 and became predominant during the 2004-2005 epidemic. During the 2006-2007 epidemic, an influenza B outbreak occurred in Taiwan and only Victoria lineage viruses circulated. We characterized the viruses isolated in the 2006-2007 epidemic and found that the HA genes of influenza B viruses from that epidemic were highly similar to those from the 2004-2005 epidemic. We also analyzed the NA genes of isolates from the 2006-2007 epidemic and found that they all belonged to the Yamagata lineage and formed a new genetic subclade. Comparison of isolates from the 2004-2005 and 2006-2007 epidemics revealed four substitutions, N220K, E320D, K343R and E404K in NA genes. Although the HA sequences from the 2006-2007 epidemic were similar to those from the 2004-2005 epidemic, the NA sequences differed, suggesting distinct patterns of evolution of the HA and NA genes from 2004-2007 in Taiwan. This study emphasizes that the evolution of the NA genes may contribute to reemergence of influenza B viruses. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：243 / 249

页数：7