Olfaction as a biomarker in Parkinson's disease

被引：19
|
作者：
Morley, James F. [1 ,2 ]
Duda, John E. [1 ,2 ]
机构：
[1] Univ Penn, Sch Med, Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
来源：
BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 05期
关键词：
diagnosis; dopaminergic functional imaging; neuropathology; olfaction; olfactory bulb; Parkinson's disease; parkinsonian disorders; pathophysiology; smell; SMELL IDENTIFICATION TEST; LEWY BODY DISEASE; ODOR IDENTIFICATION; TRANSCRANIAL SONOGRAPHY; ALPHA-SYNUCLEINOPATHY; COGNITIVE IMPAIRMENT; CLINICAL-DIAGNOSIS; DE-NOVO; DYSFUNCTION; PATHOLOGY;
D O I：
10.2217/BMM.10.95
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Olfactory dysfunction in Parkinson's disease is common and of interest, both as a clinical finding and potential biomarker. In this article, we discuss studies characterizing the olfactory deficit in Parkinson's disease and pathological analysis that suggests the olfactory system is a likely induction site of the neurodegenerative process. These studies have enabled research to explore the potential of olfactory dysfunction as a key component in early diagnostic strategies, as a biomarker for diagnostic purposes, a predictor of clinical outcomes and a potential therapy-independent marker of disease progression.
引用
收藏
页码：661 / 670
页数：10
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