The cytokine gene polymorphisms in patients with chronic kidney graft rejection

被引：22
|
作者：
Pawlik, A
Domanski, L
Rozanski, J
Florczak, M
Wrzesniewska, J
Dutkiewicz, G
Dabrowska-Zamojcin, E
Gawronska-Szklarz, B
机构：
[1] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Transplantol Neprhol & Internal Dis, Szczecin, Poland
来源：
TRANSPLANT IMMUNOLOGY | 2005年 / 14卷 / 01期
关键词：
kidney allograft; chronic rejection; cytokine; polymorphism;
D O I：
10.1016/j.trim.2004.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic allograft rejection remains an important cause of morbidity after kidney transplantation. The aim of the study was to examine the association between IL-2, IL-6 and TNF-a promoter polymorphisms and chronic kidney allograft rejection. The study included 64 patients with long-term stable graft function and 62 with chronic allograft nephropathy. Among patients with chronic allograft nephropathy a statistically significant prevalence of the IL-6 CC genotype associated with low IL-6 expression was observed (p < 0.01, OR 3.18; 95% CI 1.27-8.15). There were no statistically significant differences in distribution of IL-2 and TNF-alpha genotypes between patients with stable graft function and chronic allograft rejection. The results of present study suggest that the genetically determined low IL-6 production may be the risk factor of chronic allograft nephropathy development. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：49 / 52
页数：4
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