With the present landscape in the healthcare organizations, job satisfaction in the nursing sector must be put into scrutiny as more and more nurses quit due to organizational issues. This study aims to factor-in the socio-demographic information of the nurses working in the Hail region, Kingdom of Saudi Arabia, which can influence their job satisfaction. Specifically, it aims to determine the job satisfaction level of nurses and significant differences in their socio-demographic information. The researcher employed a quantitative cross-sectional design to investigate the job satisfaction of nurses in the Hail region, Kingdom of Saudi Arabia. The researcher utilized the MSQ "short form," which has 20 of the 100 original items. Data gathering was conducted from January to April 2019. Statistically, the weighted mean was used to determine the level of job satisfaction, F-test (one-way ANOVA) and t-test were also employed. This research has obtained ethical approval from the Ethics review board of the University of Hail (H-2016-059). The nurse respondents were satisfied in their present job (M=3.50; SD=1.15). Significant differences have been found in regards to civil status (p=0.01), nationality (p=0.01), age (p=0.03), salary range (p=0.01), and total years of experience (0.01). Factors influencing job satisfaction of nurses in the Hail region, Kingdom of Saudi Arabia such as civil status, nationality, age, salary, and the total years of experiences are vital in planning the strategies to address the turnover. Policymakers can utilize these factors to increase the motivation of these nurses, thereby improving patient outcomes. (C) 2020 The Authors. Published by IASE.